During the last year a new population of galaxies at high redshift (z=2.5-3.5) has been identified which may represent the long sought-after population of protogalaxies -- the progenitors of normal galaxies like the Milky Way, observed in their initial episode of star-formation. We propose to use ISO to study the spectral energy distribution of MS1512-cB58 at z=2.72, which is by far the brightest example in its class -- 3 magnitudes brighter than any other known high redshift protogalaxy candidate. We will combine ISOCAM LW2 and LW3 photometry, and LWS1 low resolution spectroscopy from 43-197 microns, with a large body of ground-based spectrophotometry and HST photometry to measure the current star-formation rate, reddening, star-formation history, and dust mass in cB58. The observed mid-IR measured with ISOCAM corresponds to the rest frame H and K band, and so will place important constraints upon the presence of any old population of stars. The far-IR spectral energy distribution obtained with the LWS will be combined with ground-based sub-millimeter bolometry to estimate the temperature and mass of the dust in this galaxy.